Treatment for Smile Lines and Wrinkles in the Nasolabial Folds

Bellafill® is approved is approved by Health Canada for the correction of facial wrinkles known as nasolabial folds, or smile lines. Only one dermal filler is proven safe through 5 years.

Based on 5-Year Post-Approval Study for the correction of nasolabial folds. **The indication for correction of nasolabial folds (smile lines) was approved based on a pivotal clinical study, where effectiveness was observed out to 12 months (primary effectiveness endpoint was at 6 months).

Look younger for longer with Bellafill® smile line treatment.

Ask your licensed provider if Bellafill® is right for you.

Before & after photos

Immediate correction and lasting improvement to nasolabial folds through 5 years.

Bellafill® offers a new level of filler rejuvenation. The collagen immediately adds volume to smooth away facial wrinkles known as smile lines, and the polymethylmethacrylate (PMMA) microspheres help your skin re-create its own firmer structure for beautiful, younger-looking skin and lasting results.1,4*

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*Proposed mechanism of action

What is Bellafill® and what makes it unique?

It is distinctive

In the world of injectables, Bellafill® is distinctive. The collagen immediately adds volume to the skin to lift wrinkles known as smile lines. The PMMA microspheres create a matrix that supports your body’s own collagen production.1,4*

Health Canada approved

Bellafill® has been approved by Health Canada for the correction of wrinkles known as smile lines since 2011.

Proven safe

Bellafill® isn’t just an exceptional cosmetic treatment option. It was proven safe through 5 years for the correction of nasolabial folds or smile lines in the largest and longest prospective dermal filler study ever completed.2

Bellafill® is a polymethylmethacrylate (PMMA) collagen filler

  • See visible correction with the very first treatment.

  • The collagen in Bellafill® provides immediate volume and lift while the PMMA microspheres remain in place and create a matrix that supports collagen production in your skin for lasting improvement.1*

Gel immediately after injection

Gel at 4 months1*

Collagen tissue matrix and blood vessels have formed around PMMA

*Proposed mechanism of action

References: 1. Gottfried Lemperle, et. al., ArteFill® Permanent Injectable for Soft Tissue Augmentation: I. Mechanism of Action and Injection Techniques., Aesthetic Plast Surg. 2010 Jun;34(3):264–72. 2. Bellafill® [Instructions for Use]. San Diego, CA: Suneva Medical, Inc.; 2015. 3. Jacob CI, Dover JS, Kaminer MS. Acne scarring: A classification system and review of treatment options. J Am Acad Dermatol; July 2001; 109-117. 4. Data on file. Suneva Medical, Inc. 5. Haneke et al. Polymethyl Methacrylate Microspheres in Collagen. Semin Cutan Med Surg 23:227-232,2004. 6. Cohen et al. Artecoll: A Long-Lasting Injectable Wrinkle Filler Material: Report of a Controlled, Randomized, Multicenter Clinical Trial of 251 Subjects. Plast. Reconstr. Surg. 114: 964,2004.

Is Bellafill® right for me?

It’s a difference you can feel

Treatment with Bellafill® is very similar to treatment with conventional fillers. Bellafill® immediately adds volume to wrinkles known as smile lines for a smoother, more youthful appearance. In addition, Bellafill® re-creates the firm structure of younger-looking skin by supporting production of your body’s own collagen. Bellafill® requires an optional skin test to identify those patients who may have an allergy to lidocaine or bovine collagen.1*

The beautiful benefits of Bellafill®

  • Immediate correction and lasting improvement with visible benefits through 5 years for wrinkles known as smile lines.4
  • PMMA helps replace lost collagen by working with your body’s natural processes.1*
  • A simple, in-office treatment with little to no downtime. You can immediately resume your normal daily activities.
  • Injection comfort with 0.3% lidocaine.4
  • Satisfied patients. In a consumer survey, 91% of patients were likely to recommend Bellafill.4 In a 5-Year Post-Approval Study, 83% of patients were satisfied to very satisfied with their nasolabial fold correction at the end of 5 years.2

*Proposed mechanism of action.

References: 1. Gottfried Lemperle, et. al., ArteFill® Permanent Injectable for Soft Tissue Augmentation: I. Mechanism of Action and Injection Techniques., Aesthetic Plast Surg. 2010 Jun;34(3):264–72. 2. Bellafill® [Instructions for Use]. San Diego, CA: Suneva Medical, Inc.; 2015. 3. Jacob CI, Dover JS, Kaminer MS. Acne scarring: A classification system and review of treatment options. J Am Acad Dermatol; July 2001; 109-117. 4. Data on file. Suneva Medical, Inc. 5. Haneke et al. Polymethyl Methacrylate Microspheres in Collagen. Semin Cutan Med Surg 23:227-232,2004. 6. Cohen et al. Artecoll: A Long-Lasting Injectable Wrinkle Filler Material: Report of a Controlled, Randomized, Multicenter Clinical Trial of 251 Subjects. Plast. Reconstr. Surg. 114: 964,2004.

Wrinkles caused by repetitive movement

Repeated movement of the facial skin may create wrinkles. These types of wrinkles are “dynamic.” Age is a factor, but repeated facial movements, such as frowning or squinting, can also create lines, which means they may develop even in younger adults. These wrinkles are not candidates for Bellafill® treatment.

Wrinkles caused by volume loss and gravity

Over time, we lose volume in our faces, increasing the chances for wrinkles and folds to appear. The fat pads in our cheeks may slide downward toward the mouth, which can cause the skin to wrinkle or fold, creating the “smile lines” from your nose to the corners of your mouth (nasolabial folds). Bellafill® effectively addresses volume loss to reverse the signs of aging.4

Bellafill® can treat wrinkles caused by lost volume

Bellafill® replaces lost volume in the skin below the wrinkle for results that are immediate and lasting.4

Patients who have a positive reaction to the Bellafill® Skin Test, a history of severe allergies, known bovine collagen allergies, are allergic to lidocaine, have bleeding disorders or prone to thick scar formation and/or excessive scarring should not receive Bellafill®.

How Bellafill® works

Bellafill® works in two ways:

  • The collagen provides immediate volume below facial wrinkles known as smile lines to lift them to the level of the surrounding skin.4

  • The PMMA microspheres create a matrix that supports your body’s own collagen production.1*

The injectable gel is comprised of 80% purified collagen and 20% PMMA (polymethylmethacrylate) microspheres. The microspheres are half the diameter of a human hair, so small that they are virtually invisible to the eye.

And keeps on working

Bellafill® is different. It restores rather than just fills for natural enduring results. In a pivotal clinical study on nasolabial folds correction, effectiveness was observed out to 12 months (primary effectiveness endpoint was at 6 months.)4

In a 5-Year Post-Approval Study, 83% of patients were satisfied to very satisfied at the end of 5 years.2

Bellafill® is placed below the depression using a fine needle.

The injectable gel immediately adds volume to the skin to lift and smooth out wrinkles.4

The Bellafill® difference

Beauty that lasts

Do you love the more youthful look that dermal fillers provide, but wish the results weren't so temporary? Bellafill® lasts through 5 years.2


*The indication for correction of nasolabial folds (smile lines) was approved based on a pivotal clinical study, where effectiveness was observed out to 12 months (primary effectiveness endpoint was at 6 months).

Proven safe.

Bellafill® isn’t just an exceptional cosmetic treatment option. In the largest and longest prospective dermal filler study ever conducted, Bellafill® was been proven safe through 5 years for the correction of nasolabial folds or smile lines.2

Look younger for longer, naturally

Bellafill® offers a new level of filler rejuvenation. The collagen immediately adds volume to smooth away facial wrinkles known as smile lines, and the PMMA microspheres help your skin re-create its own firmer structure for beautiful, younger-looking skin and lasting results.1,4*


*Proposed mechanism of action

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